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Drug Description of Suboxone (Buprenorphine/naloxone)
Suboxone sublingual tablet is an uncoated hexagonal orange tablet, debossed with an alphanumeric word identifying the product and strength. It contains buprenorphine HCL, a partial agonist at the mu-opioid receptor, and naloxone HCl dihydrate, an opioid receptor antagonist, at a ratio of 4:1. It is intended for sublingual administration and is available in two dosage strengths, 2 mg buprenorphine with 0.5 mg naloxone and 8 mg buprenorphine with 2 mg naloxone. Suboxone is available for use in two different forms, under the tongue or in the cheek.
Uses of Suboxone
Suboxone is used to treat dependence/addiction to opioids (narcotics). Buprenorphine belongs to a class of drugs called mixed opioid agonist-antagonists. It helps prevent withdrawal symptoms caused by stopping other opioids. It is used as part of a complete treatment program for drug abuse.
Dosage and Administration
Prior to induction, consideration should be given to the type of opioid dependence (i.e., long-or short-acting opioid products), the time since last opioid use, and the degree or level of opioid dependence. Dosage should be individualized for maximum beneficial effect.
Side Effects of Use
Side effects may include respiratory depression (decreased breathing), small pupils, sleepiness, and low blood pressure. Buprenorphine, at lower doses, results in the usual opioid effects; however, high doses beyond a certain level do not result in greater effects. This is believed to result in a lower risk of overdose than some other opioids. Naloxone is an opioid antagonist that competes with and blocks the effect of other opioids (including buprenorphine) if given by injection. Naloxone is poorly absorbed when taken by mouth and it is added to decrease the risk that people will misuse the medication by injection.