Oxymorphone (Opana): Uses, Dosage & Side Effects

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Drug Description of Oxymorphone (Opana)

Oxymorphone, sold under the brand names Numorphan and Opana among others, is a white or slightly off-white, odorless powder used as an opioid pain medication. Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. The elimination half-life of oxymorphone is much faster intravenously, and as such, the drug is most commonly used orally.

Uses of (Opana)

Oxymorphone Immediate Release is indicated for the relief of moderate to severe pain, such as treatment of acute post surgical pain. 

Opana extended-release tablets are indicated for the management of chronic pain and only for people already on a regular schedule of strong opioids for a prolonged period. Immediate-release Opana tablets are recommended for breakthrough pain for people on the extended-release version. Compared to other opioids, Opana has similar pain relieving efficacy

Dosage and Administration

For Subcutaneous or intramuscular administration: initially 1 mg to 1.5 mg, repeated every 4 to 6 hours as needed. In non debilitated patients the dose can be cautiously increased until satisfactory pain relief is obtained.

One suppository, 5 mg, every 4 to 6 hours. In non debilitated patients the dose can be cautiously increased until satisfactory pain relief is obtained.

Side Effects of Use

As with all potent opioid analgesics, possible side effects when using this drug include:

Drowsiness, sedation, lightheadedness, headache, blurred vision, nervousness, restlessness, confusion, mental clouding, trouble sleeping, mental depression, Nausea, vomiting, dry mouth, constipation and loss of appetite.