Amobarbital Sodium: Uses, Dosage & Side Effects

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Drug Description of Amobarbital Sodium

Amobarbital Sodium sold under the brand name of Amytal Sodium among others, is a central nervous system (CNS) depressants which is primarily used as sedative hypnotics. In sub hypnotic doses, It also used as anticonvulsants. It is a white, friable, granular powder that is odorless with a slightly bitter taste. If Amobarbital is taken for extended periods of time, physical and psychological dependence can develop.

Uses Of Amobarbital Sodium

Amobarbital is used for the treatment of:

• Anxiety Disorders
• Seizures
• Sleep Initiation and Maintenance Disorders
• Status Epilepticus

Dosage and Administration

The dose of amobarbital sodium must be individualized with full knowledge of its particular characteristics and recommended rate of administration. Factors of consideration are the patient’s age, weight, and condition. The maximum single dose for an adult is 1 g.

Intramuscular Use

Intramuscular injection of the sodium salts of barbiturates should be made deeply into a large muscle. The average intramuscular dose ranges from 65 mg to 0.5 g. A volume of 5 mL (irrespective of concentration) should not be exceeded at any one site because of possible tissue irritation. Twenty percent solutions may be used so that a small volume can contain a large dose.

Intravenous Use

Intravenous injection is restricted to conditions in which other routes are not feasible, either because the patient is unconscious, because the patient resists, or because prompt action is imperative. The rate of IV injection for adults should not exceed 50 mg/min to prevent sleep or sudden respiratory depression. The final dosage is determined to a great extent by the patient’s reaction to the slow administration of the drug.

Adults:

1. Sedative: 30 to 50 mg given 2 or 3 times daily.
2. Hypnotic: 65 to 200 mg at bedtime.

Side Effects of Use

Common side effects include Agitation, CNS depression, nightmares, nervousness, hallucinations, insomnia, anxiety, dizziness, abnormality in thinking, Nausea, vomiting and constipation