2-Methyl-1-phenyl-2-(3-pyridinyl)-1-propanone (2-MPPP) is an opioid analgesic structurally derived from 2-Aminopropan-1, in which the Nitrogen is connected to the Carbon in the 3-position. Chemically, it is a reversed ester of pethidine which has about 70% of the potency of morphine. Unlike its derivative prodine, it was not reported to exhibit optical isomerism It was reported to have 30 times the activity of pethidine and a greater analgesic effect than morphine in rats, and it was demonstrated to cause central nervous system stimulation in mice
2-MPPP may be utilized by researchers who wish to use it as a reference sample for their Gas chromatography/mass spectrometry (GC/MS), Fourier transform infrared spectroscopy(FTIR) or Nuclear magnetic resonance(NMR) analysis catalogues.
2-MPPP is supplied as a white crystalline solid. It is soluble in organic solvents such as methanol, DMSO, and dichloromethane (DCM), which should be purged with an inert gas. The solubility of 2-MPPP in ethanol and DMF is about 22 mg/ml and approximately 15 mg/ml in DMSO.
Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of 2-MPPP can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility 2-Methyl-1-phenyl-2-(3-pyridinyl)-1-propanone in PBS, pH 6.4, is approximately 11 mg/ml. We do not recommend storing the aqueous solution for more than one day.
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